Publication date: 2018-04-23 23:27
Stimulation may be evident, especially in children and geriatric patients. Convulsions may rarely occur. A paradoxical-type reaction has been reported in children receiving single doses of 75 mg to 675 mg orally, characterized by hyperexcitability and nightmares.
Promethazine hydrochloride tablets should be used cautiously in persons with cardiovascular disease or with impairment of liver function.
It is not known whether promethazine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Atropine-like signs and symptoms - dry mouth , fixed, dilated pupils, flushing, as well as gastrointestinal symptoms - may occur.
Promethazine is used for several reasons, including treating allergies, motion sickness, nausea and vomiting, anxiety before surgery, and pain after surgery. It’s also used as a sleep aid, including before and after surgery.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.
This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Get medical help right away if you have any of the following symptoms: fever, muscle stiffness/pain/tenderness/ weakness , severe tiredness, severe confusion, sweating , fast/irregular heartbeat, dark urine, signs of kidney problems (such as change in the amount of urine).
Parenteral: 75 mg IV or IM, followed by close observation for response. This dose may be repeated within 7 hours if needed. Oral therapy should be started as soon as feasible if continued medication is required.
Oral: 75 mg at bedtime. Alternatively, mg may be administered before the evening meal and again at bedtime for antihistamine effects.
Rectal: 75 mg at bedtime. Alternatively, mg may be administered before the evening meal and again at bedtime for antihistamine effects.
Always use this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
Promethazine is contraindicated for use in patients with a known phenothiazine hypersensitivity. Cross-sensitivity may occur. This contraindication includes patients who have experienced agranulocytosis, blood dyscrasias, bone marrow suppression, or jaundice due to phenothiazine therapy. Promethazine is also contraindicated in patients who are in a coma.