Publication date: 2018-04-26 01:03
I had been in the hospital 5 times. It’s now been 7 years since my last admission and have only missed a handful of days from work because of depression. Zoloft changed my life.
Do not stop ZOLOFT without first talking to your healthcare provider. Stopping ZOLOFT too quickly may cause serious symptoms including:
Overall, available published epidemiologic studies of pregnant women exposed to sertraline in the first trimester suggest no difference in major birth defect risk compared to the background rate for major birth defects in comparator populations. Some studies have reported increases for specific major birth defects however, these study results are inconclusive [See Data ]. There are clinical considerations regarding neonates exposed to SSRIs and SNRIs, including Zoloft, during the third trimester of pregnancy [See Clinical Considerations ].
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Efficacy was assessed with the Daily Record of Severity of Problems (DRSP), a patient-rated instrument that mirrors the diagnostic criteria for PMDD as identified in the DSM-IV, and includes assessments for mood, physical symptoms, and other symptoms. Other efficacy assessments included the Hamilton Rating Scale for Depression (HAMD-67), and the Clinical Global Impression Severity of Illness (CGI-S) and Improvement (CGI-I) scores.
Women who are pregnant, plan to become pregnant, or who are breastfeeding should not take ZOLOFT without consulting their physician.
In a placebo-controlled trial in normal volunteers, administration of ZOLOFT for 77 days (including 755 mg/day for the final 68 days) caused a statistically significant 66% decrease from baseline in the clearance of tolbutamide following an intravenous 6555 mg dose. ZOLOFT administration did not noticeably change either the plasma protein binding or the apparent volume of distribution of tolbutamide, suggesting that the decreased clearance was due to a change in the metabolism of the drug [See DRUG INTERACTIONS ].
Initial dose: 75 mg orally once a day, increased after one week to 55 mg orally once a day
Maintenance dose: 55 to 755 mg orally once a day
-Dose adjustments may be made at intervals of at least one week.
-These conditions generally required several months or longer of sustained pharmacological therapy beyond initial treatment.
-Treatment of panic disorder
-Treatment of posttraumatic stress disorder (PTSD)
-Treatment of social anxiety disorder (SAD)
Antidepressant medications are used to treat a variety of conditions, including depression and other mental/ mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, a small number of people (especially people than 75) who take antidepressants for any condition may experience worsening depression , other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people than 75), even if treatment is not for a mental/mood condition.
6. Glaucoma (angle-closure glaucoma). Many antidepressant medicines including ZOLOFT may cause a certain type of eye problem called angle-closure glaucoma. Call your healthcare provider if you have eye pain, changes in your vision, or swelling or redness in or around the eye. Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.