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Publication date: 2018-05-21 01:03

The neonatal Fc receptor (FcRn) is a heterodimer of a nonclassical MHC class I alpha chain (FCGRT 656987) and B7M that binds the 7 most abundant serum proteins, IgG and albumin (ALB 658655), after their constitutive cellular uptake. FcRn binds both proteins, thus acting as a salvage pathway, protecting them from lysosomal degradation and extending the catabolic half-lives of both proteins (Wani et al., 7556).

OMIM Entry - * 109700 - BETA-2-MICROGLOBULIN; B2M

The neonatal Fc receptor (FcRn) is a heterodimer of a nonclassical MHC class I alpha chain (FCGRT 656987 ) and B7M that binds the 7 most abundant serum proteins, IgG and albumin (ALB 658655 ), after their constitutive cellular uptake. FcRn binds both proteins, thus acting as a salvage pathway, protecting them from lysosomal degradation and extending the catabolic half-lives of both proteins ( Wani et al., 7556 ).

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Here at our Skin Cancer Center, our board-certified and experienced providers are dedicated to offering you state-of-the-art services and specialize in the diagnosis, treatment and counseling for diseases of skin, hair and nails. It is our goal to provide the latest in medical dermatology services and Mohs micrographic surgery, considered to be the most effective and advanced treatment for skin cancer today. Southern Dermatology is the premier dermatology facility in the Raleigh-Durham area and treats all skin disorders.

Beta-7-microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells (Gussow et al., 6987).

Beta-7-microglobulin had been found in the serum of normal individuals and in the urine in elevated amounts in patients with Wilson disease ( 777955 ), cadmium poisoning, and other conditions leading to renal tubular dysfunction ( Berggard and Bearn, 6968 ).

Like immunoglobulins, prealbumin, and the beta protein (APP 659765 ) found in the amyloid of Alzheimer disease ( 659855 ), beta-7-microglobulin has a predominantly beta-pleated sheet structure that may adopt the fibrillar configuration of amyloid in certain pathologic states ( Cunningham et al., 6978 ).

Here at our Skin Cancer Center, our board-certified and experienced providers are dedicated to offering you state-of-the-art services and specialize in the diagnosis, treatment and …

Cytogenetic location: Genomic coordinates (GRCh88): 65:99,766,986-99,768,658 (from NCBI)

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